Risk-adapted Therapy of Pediatric Hodgkin Lymphoma in Upper Egypt
نویسندگان
چکیده
Hodgkin's lymphoma (HL) is a highly curable malignant disease. Contemporary treatment for children and adolescents with Hodgkin’s disease often uses a combined-modality approach with multi-agent chemotherapy and involved-field radiotherapy. This approach has yielded excellent results, with long-term disease-free survival ranged from 85% to 100% in patients with early-stage disease and of more than 60% in those with more advanced disease [1]. Because cure is likely for the majority of children presenting with HL, attention to long-term treatment complications has become increasingly important. Risk-adapted therapy for children with HL is directed toward high survival, minimal toxicity and optimal quality of life. This approach assigns intensity of therapy according to the risk criteria at presentation, with the parameters most frequently used to assign risk are the presence of "B" symptoms, bulk of presenting mass, mediastinal lymphadenopathy, extra nodal extension, number of involved nodal regions and Ann Arbor stage [2]. The objectives of this study are to assess the outcome of the HL patients treated with risk-adapted therapy approach at pediatric oncology department in South Egypt Cancer Institute (SECI) and to assess the prognostic factors of survival in pediatric HL patients.
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